Regulation of Blood Long-Term Ouabain Long-Evans Rats
نویسندگان
چکیده
We tested whether ouabain, an inhibitor of the sodium pump, can lead to chronic hypertension in Long-Evans rats using sensitive 24-h measurements of blood pressure. After a control week of vehicle isotonic saline infusion (14.4 ml/day), ouabain was infused intravenously at 30 pg/kg/day in intact (2K) and uninephrectomized UK) Long-Evans rats for a total of 4 weeks. Although plasma ouabain concentration rose to 0.97 f 0.15 nmoYL with ouabain infusion, mean arterial pressure did not change in either 2K (A = -0.6 f 1.3 mm Hg) or 1K (A = -1.2 + 0.7 mm Hg) rats. These data suggest that Long-Evans rats are insensitive to the hypertensive effects of ouabain. Am J Hypertens 1999;12:423-426
منابع مشابه
Regulation of blood pressure during long-term ouabain infusion in Long-Evans rats.
We tested whether ouabain, an inhibitor of the sodium pump, can lead to chronic hypertension in Long-Evans rats using sensitive 24-h measurements of blood pressure. After a control week of vehicle isotonic saline infusion (14.4 mL/day), ouabain was infused intravenously at 30 microg/kg/day in intact (2K) and uninephrectomized (1K) Long-Evans rats for a total of 4 weeks. Although plasma ouabain ...
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تاریخ انتشار 2004